Note for Guidance for Food Contact Materials
Page 106 of 126
Two primary solutions of analyte standard should be
prepared and checked against one another with one dilution
only. If there is agreement within 5% then further dilute
standards are made from only one of the primary standards.
Avoid weights of analyte and internal standard larger than
150 mg and also avoid volumes of solvent greater than
set out conditions of storage and maximum storage time for
solutions, as obtained from stability tests.
4.1 [SPECIAL] =
set out special equipment e.g.:
gas chromatograph, equipped with:
automatic headspace sampler
set out column requirements, such as:
the column must exhibit reasonable peak shape with
respect to half-width and asymmetry and must
permit the separation of analyte and internal standard
the column must exhibit minimum overlap of peaks
of analyte and internal standard and other
substances. A check should be specifically carried
out on interference with the internal standard.
set out examples of columns that have been found suitable
for analyte determination - include details of type,
dimensions, column flow, temperature etc.
set out conditions of storage of samples
Analytical determinations should be carried out on duplicate
samples, these being duplicate portions of [MATRIX], with
at least duplicate measurements (injections) of the final
set out test sample preparation.