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- Practical Guide -
Page 133 of 153
CRITERIA APPLIED BY THE SCF FOR THE
EVALUATION OF SUBSTANCES
1.
INTRODUCTION
The "SCF Guidelines" not always explicitly inform about the criteria of SCF for the
evaluation of a substance and the specification of quantitative restrictions. This document
summarises these criteria as far as possible in order to provide basic information, but also as
pro-memoria² to avoid discrepancies in future evaluations.
However it should be noted that this document was prepared many years ago and, therefore,
does not necessarily represent now the SCF opinion.
2.
ALLOCATION TO SCF LISTS.
2.1
The SCF classified the substances included in Synoptic document in ten lists ("SCF
lists") defined as reported in the document "Note for Guidance". The criteria applied
for this classification are included and will not be repeated here. However it could be
useful
a)
To repeat some criteria as a pro memoria and underline aspects for the allocation
of substances in lists 6 (6A and 6B), 7, 8 and 9, because recently some detailed
criteria have been defined for these lists;
b)
To better explain the criteria used by the SCF for the establishment of a TDI or
other quantitative restrictions.
2.2. List 6
The SCF stated that "allocations of substances to this list are mainly based upon
similarity of structure of chemical substances already evaluated or known to have
functional groups that indicate carcinogenic or other severe toxic properties".
2.2.1 List 6A
The SCF recently expressed the opinion that the following compounds are "suspected
to have carcinogenic properties":
-
Acrylamides and methacrylamides
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Allyl compounds
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Crotonyl compounds
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Epoxy compounds
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Hydrazides
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Vinyl compounds