(Gig. Sanit. 34, 1969, 114, EPA 560/11-80-
011, April 1980).
1-year oral rat study inadequate.
(Allied Chem. Corp. 1958).
TDI: 1 mg/kg b.w.
A 90-day oral rat study.
(Hilltop Research Inst. Inc. January 3,
Same 22720 DIR/D
R= not detectable.
Available: Inadequate migration data,
inadequate mutagenicity studies, acute
tox.data, 28-day oral rat study, two 90-day
oral rat studies, reproduction study (special
design), excretion study, skin and eye
irritation studies, two oestrogenic studies.
Needed: Confirmation of the claim of non-
detectability at 5 ppb level; information on
the composition of the test samples
(particularly the amount of 4-(1,1,3,3-
tetramethylbutyl)phenol used in the
polycondensation process should be
indicated); reasons for deviation from
standard test conditions in migration
experiments; a more extensive description of
the method of determination (preferably
according to the standard format) and
sufficient information to allow evaluation of
the data provided; detailed data on the level
of 4-tert.octylphenol in the recovery
experiments. In vitro chromosomal
aberration assay in cultured mammalian
cells; dependent of the outcome of the