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REF_N
CAS_N
NAME
SYNONIM
DIR
RESTRICTIONS
AND
SPECIFICATIONS
SCF
List
EFSA/SCF_OP
PL
CT
146
39890
087826-41-3
and 069158-
41-4 and
054686-97-
4/081541-
12-0
Bis(methylbenzylidene)
sorbitol
DIR
2
Group TDI: 1 mg/kg b.w. (with bis(4-
ethylbenzylidene)sorbitol and
bis(methylbenzylidene) sorbitol).
28- and 90-day oral rat studies, one in-vitro
mutagenicity study.
See references for bis(4-
ethylbenzylidene)sorbitol.
+
+
39920
000085-60-9 1,1-Bis(2-methyl-4-
hydroxy-5-tert-
butylphenyl)butane
Same 40770
7?
Available: data from 30- and 90-day oral rat
studies inadequate.
Needed: in first instance migration and
mutagenicity data.
+
39925
129228-21-3 3,3-Bis(methoxymethyl)-
2,5-dimethylhexane
DIR SML = 0.05 mg/kg
3
R: 0.05 mg/kg of food.
Available: worst case migration levels based
on compositional analysis and assumption
of 1000% migration from 250 um layer
thickness; gene mutation assay in bacteria
(negative); chromosomal aberration assay in
cultured mammalian cells (negative); two
gene mutation assays in cultured mammalian
cells (positive); in vivo UDS assay in rat
liver (negative); in vivo micronucleus assay
(negative).
(RIVM/ISS/UK SDS, November 1998 =
CS/PM/3223 REV. I/39925).

Remark for Commission: No method of
analysis for the determination of an SML is
available.

(Adopted at 116th SCF meeting) (24 March
1999)
http://europa.eu.int/comm/food/fs/sc/scf/out
27_en.pdf
+
39980
-
Bis(N,N'-methyl-beta-
hydroxyethyl)-
hexamethylenebisurea
8
+
40000
000991-84-4 2,4-Bis(octylmercapto)-
6-(4-hydroxy-3,5-di-tert-
butylanilino)-1,3,5-
DIR SML = 30 mg/kg
2
TDI: 0.5 mg/kg b.w.
90-day oral rat and dog studies.
(RIVM monograph 300/211, December
+
+