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REF_N
CAS_N
NAME
SYNONIM
DIR
RESTRICTIONS
AND
SPECIFICATIONS
SCF
List
EFSA/SCF_OP
PL
CT
156
(RIVM doc. December 1983).
43650
000075-68-3 1-Chloro-1,1-
difluoroethane
W7? Available: semichronic and chronic
inhalation studies in rats, 2 inhalation
teratogenicity studies in rats, several Ames
tests and two in vivo mutagenicity studies,
migration data.
Needed: reproduction study.
+
43680
000075-45-6 Chlorodifluoromethane
DIR SML = 6 mg/kg and in
compliance with the
specifications laid
down in Annex V.
2
TDI: 0.1 mg/kg b.w. (based on
teratogenicity study).
Specification: content of
chlorofluoromethane less than 1 ppm.One
year oral rat study. Several inhalation studies
in several animal species, including
teratogenicity in rabbits. Mutagenicity tests
in-vitro and in-vivo.

N.B. The Committee has not considered the
environmental implications of the use of the
solvent in food technology, but recognises
that environmental considerations may take
precedence over its own evaluations on this
occasion.
+
43760
026172-55-4 5-Chloro-2-methyl-4-
isothiazolin-3-one
7
90-day oral rat and dog studies.
Reproduction and teratogenicity studies in
rabbits, 3 mutagenicity studies.
(RIVM Doc.Tox.300/430 May 1979,
September 1983, June 1984). Very potent
sensitizer.
+
+
43820
-
Chromic chloride
complex with linear
sat.monocarb.acids (C16
and above)
D
+
43840
015659-56-0 Chromic chloride
myristate
8
+
43920
015242-96-3 Chromic chloride
stearate
9
+
43980
001308-38-9 Chromium (III) oxide
9
+
44000
001333-82-0 Chromium trioxide
5
Cr(VI) is a genotoxic carcinogen (IARC
monograph 1980, vol. 23).
+