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REF_N
CAS_N
NAME
SYNONIM
DIR
RESTRICTIONS
AND
SPECIFICATIONS
SCF
List
EFSA/SCF_OP
PL
CT
269
migration level (see SCF guidelines) and, if
migration exceeds 0.05 mg/kg peroxisome
proliferation studies too.
85280
052829-07-9 Sebacic acid, bis(2,2,6,6-
tetramethyl-4-piperidyl)
ester
7
Available: 4 mutagenicity studies.
Needed: migration data, use, stability during
production and use.
+
85360
000109-43-3 Sebacic acid, dibutyl
ester
DIR
3
Toxicologically acceptable (hydrolyses in
intestinal fluid to sebacic acid and butanol).

Available: migration data in olive oil;
hydrolysis data; inadequate semichronic oral
rat and chronic oral rat and reproduction
study; inadequate Ames test; inadequate
Drosophila study; inadequate micronucleus
assay; three adequate in vitro mutagenicity
studies; peroxisome proliferations study.
(RIVM/TNO July 1996,=CS/PM/2860)
+
+
85440
000106-79-6 Sebacic acid, dimethyl
ester
Same 24370
8
Group R: 0.05 mg/kg b.w.
Needed: toxicological data depending on
migration level (see SCF guidelines) and, if
migration exceeds 0.05 mg/kg peroxisome
proliferation studies too.
+
85520
002432-87-3 Sebacic acid, di-n-octyl
ester
8
Group R: 0.05 mg/kg b.w.
Available: "data inadequate"(extract from
Lefaux book".
Needed: toxicological data depending on
migration level (see SCF guidelines) and, if
migration exceeds 0.05 mg/kg, peroxisome
proliferation studies too.
+
85550
009000-59-3 Shellac
Same 24440
1
ADI: acceptable.
(SCF, 26th Series, 1992).
+
85580
007631-86-9 Silica
Same 86240
D
+
85600
-
Silicates, natural
D
3
Inert material. Some specific silicates have
been allocated an ADI, not specified.
(SCF, 25th Series, 1991)
+
+
85601
-
Silicates, natural (with
the exception of
asbestos)
Same 85600
DIR
3
+
85610
-
Silicates, natural,
DIR
3
Inert material.
+
+