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REF_N
CAS_N
NAME
SYNONIM
DIR
RESTRICTIONS
AND
SPECIFICATIONS
SCF
List
EFSA/SCF_OP
PL
CT
52
15270
002783-17-7 1,12-Diaminododecane
D
8
+
15272
000107-15-3 1,2-Diaminoethane
Same 16960
and 53540
DIR See "Ethylenediamine"
+
+
15274
000124-09-4 1,6-Diaminohexane
Same 18460
and 59240
DIR See
"Hexamethylenediamin
e"
+
+
15280
000542-02-9 2,4-Diamino-6-methyl-
1,3,5-triazine
Same 10155
D
8
Data inadequate.
+
15295
000373-44-4 1,8-Diaminooctane
D
8
+
15310
000091-76-9 2,4-Diamino-6-phenyl-
1,3,5-triazine
Same 13075
DIR QMA = 5 mg/6 dmē
3
Restriction : 5 mg/kg of food. Based on the
reduced core set of toxicological data
according to the migration level.
Available : migration data on aqueous food
simulants and 50% ethanol ; log Po/w ; gene
mutation assay in bacteria (negative) ; gene
mutation assay in cultured mammalian cells
(slightly positive at only toxic doses) ;
chromosomal aberration assay in cultured
mammalian cells (positive) ; micronucleus
assay (equivocal) ; micronucleus assay with
extended sampling time (72h) and scoring of
at least 2000 PCE's per animal (negative) ;
90-day oral rat study and 18 months oral
carcinogenicity studies in mice and rats
(limited studies due to too few animals and
the use of only 2 dose levels).
RIVM/ISS/FR/TNO SDS, October 2001 =
CS/PM/3469 REV. IV/15310.
Remark for Commission: primary amines
can react with oil constituents and therefore
a QMA seems an appropriate type of limit.
(Adopted at the 130th SCF meeting, 13
December 2001)
http://europa.eu.int/comm/food/fs/sc/scf/out
115_en.pdf
+
+
15340
000109-76-2 1,3-Diaminopropane
D
8
+
15355
025513-64-8 Mixture of (40% w/w)
1,6-diamino-2,2,4-
trimethylhexane and
Same 22331
3
Re-evaluation to align this evaluation with
other evaluations done by the SCF.
R = 5 mg/6 dm2.
+