background image
REF_N
CAS_N
NAME
SYNONIM
DIR
RESTRICTIONS
AND
SPECIFICATIONS
SCF
List
EFSA/SCF_OP
PL
CT
54
Dicarboxydiphenoxyetha
ne
15490
002215-89-6 4,4'-Dicarboxydiphenyl
ether
D
8
+
15520
004919-48-6 4,4'-Dicarboxydiphenyl
sulphide
D
8
+
15550
002449-35-6 4,4'-Dicarboxydiphenyl
sulphone
D
8
+
15565
000106-46-7 1,4-Dichlorobenzene
DIR SML = 12 mg/kg
2
TDI : 0.2 mg/kg bw.
A 4-week oral rat study, 3 and 6 month oral
rat and mouse studies, teratogenicity study,
mutagenicity studies not showing
genotoxicity. Oral carcinogenicity studies in
mice and rats indicate that there is limited
evidence of carcinogenic potential in
experimental animals.
(NTP report n. 319, NIH publ, 87-2575,
RIVM report 710401005 April 1991).
+
+
15580
001653-19-6 2,3-Dichloro-1,3-
butadiene
D
6A
+
15610
000080-07-9 4,4'-Dichlorodiphenyl
sulphone
DIR SML = 0.05 mg/kg
3
R = 0.05 mg/kg of food. Based on the
reduced core set of toxicological data
according to the migration level, see
Appendix 2
Available: migration data (< 0.05 mg/kg of
food); gene mutation assay in bacteria
(negative); two gene mutation assays in
cultured mammalian cells (one negative and
one positive); micronucleus assay (negative,
however substance did not reach the bone
marrow); in vitro/in vivo UDS assay
(negative).
RIVM/ISS SDS, May 2000 = CS/PM/3062
REV.I/15610.
(Adopted at the 126th SCF meeting, 28
February 2001)
http://europa.eu.int/comm/food/fs/sc/scf/out
84_en.pdf
+
+
15640
000156-59-2 cis-1,2-Dichloroethylene
D
8
+