DIR SML(T) = 6 mg/kg
Group TDI: 0.1 mg/kg b.w. (for 4,4'-
90-day oral rat studies (2,2'-dihydroxy-4-
octyloxybenzophenone) a 18-week oral dog
octyloxybenzophenone) and 2-year rat and
dog studies (2-hydroxy-4-n-
octyloxybenzophenone), a reproduction
octyloxybenzophenone) plus metabolism.
(J.Occup.Med. 1969, 11, 703, Food
Cosm.Tox. 1972, 10, 41-50, RIVM report
DIR SML = 6 mg/kg
TDI: 0.1 mg/kg b.w.
90-day oral rat study and limited
(RIVM Doc/Tox 300/495 June 1984).
DIR SML = 0.05 mg/kg
R = 0.05 mg/kg of food.
Available: the substance is used as a
comonomer for kitchen utensils, mainly
intended for repeated use, and for oven
cooking; migration has been tested upto 218
°C and is always below 0.05 mg/kg food
(aqueous simulants, HB307); gene mutation
assay in bacteria (negative); chromosomal
aberration assay in cultured mammalian
cells (positive); gene mutation assay in
cultured mammalian cells (negative);
micronucleus assay (negative).
RIVM/FR/ISS/TNO SDS, February 2000 =