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REF_N
CAS_N
NAME
SYNONIM
DIR
RESTRICTIONS
AND
SPECIFICATIONS
SCF
List
EFSA/SCF_OP
PL
CT
56
60060
15970
000611-99-4 4,4'-
Dihydroxybenzophenone
Same 48720
DIR SML(T) = 6 mg/kg
(15)
2
Group TDI: 0.1 mg/kg b.w. (for 4,4'-
dihydroxybenzophenone; 2,2'-dihydroxy-4-
methoxybenzophenone;2-hydroxy-4-
hexoxybenzophenone;2-hydroxy-4-n-
octoxybenzophenone).
90-day oral rat studies (2,2'-dihydroxy-4-
methoxybenzophenone, 2-hydroxy-4-
methoxybenzophenone, 2-hydroxy-4-n-
octyloxybenzophenone) a 18-week oral dog
study (2-hydroxy-4-n-
octyloxybenzophenone) and 2-year rat and
dog studies (2-hydroxy-4-n-
octyloxybenzophenone), a reproduction
study (2-hydroxy-4-n-
octyloxybenzophenone) plus metabolism.
(J.Occup.Med. 1969, 11, 703, Food
Cosm.Tox. 1972, 10, 41-50, RIVM report
October 1972).
+
16000
000092-88-6 4,4'-Dihydroxybiphenyl
Same 48760
DIR SML = 6 mg/kg
2
TDI: 0.1 mg/kg b.w.
90-day oral rat study and limited
mutagenicity studies.
(RIVM Doc/Tox 300/495 June 1984).
+
16030
001965-09-9 4,4'-Dihydroxydiphenyl
ether
D
8
+
16060
002664-63-3 4,4'-Dihydroxydiphenyl
sulphide
D
8
+
16090
000080-09-1 4,4'-Dihydroxydiphenyl
sulphone
Same 13617
DIR SML = 0.05 mg/kg
3
R = 0.05 mg/kg of food.
Available: the substance is used as a
comonomer for kitchen utensils, mainly
intended for repeated use, and for oven
cooking; migration has been tested upto 218
C and is always below 0.05 mg/kg food
(aqueous simulants, HB307); gene mutation
assay in bacteria (negative); chromosomal
aberration assay in cultured mammalian
cells (positive); gene mutation assay in
cultured mammalian cells (negative);
micronucleus assay (negative).
RIVM/FR/ISS/TNO SDS, February 2000 =
+
+