monohydric, saturated,linear, primary (C4-
C22)" (PM/REF.N. 12375) in SCF list 3.
000822-28-6 Hexadecyl vinyl ether
Needed: hydrolysis data.
Available: calculated worst case migration <
0.012 mg/kg food; gene mutation assay in
bacteria (negative); chromosomal aberration
assay in cultured mammalian cells
(positive); gene mutation assay in cultured
mammalian cells (positive); in vivo
micronucleus assay in rats by inhalation
(negative); acute toxicity data; two 4-hour
inhalation rat studies; 28-day inhalation rat
study; metabolism study.
Needed: in first instance an in vivo
micronucleus assay with an appropriate
route (other than inhalation) and if negative
an in vivo UDS assay should be performed.
RIVM/FR/TNO SDS, February 2000 =
CS/'PM/2421 REV. II/18370.
(Adopted at the 121 SCF meeting (20 June
Available: 4-week rat study by inhalation
and mutagenicity tests.
Needed: migration data and gene mutation
in mammalian cells in vitro. If migration
exceeds 0.05 mg/kg of food, additional
study according to SCF guidelines should
DIR SML = ND (DL = 0.01
Available: gene mutation assay in bacteria
(negative); chromosomal aberration assay in
cultured mammalian cells (positive); gene
mutation assay in cultured mammalian cells
(negative); micronucleus assay (positive);
UDS assay (negative).
RIVM SDS, October 2000 = CS/PM/923