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REF_N
CAS_N
NAME
SYNONIM
DIR
RESTRICTIONS
AND
SPECIFICATIONS
SCF
List
EFSA/SCF_OP
PL
CT
69
monohydric, saturated,linear, primary (C4-
C22)" (PM/REF.N. 12375) in SCF list 3.
18340
000822-28-6 Hexadecyl vinyl ether
D
7
Needed: hydrolysis data.
+
18370
000592-45-0 1,4-Hexadiene
DIR
7
Available: calculated worst case migration <
0.012 mg/kg food; gene mutation assay in
bacteria (negative); chromosomal aberration
assay in cultured mammalian cells
(positive); gene mutation assay in cultured
mammalian cells (positive); in vivo
micronucleus assay in rats by inhalation
(negative); acute toxicity data; two 4-hour
inhalation rat studies; 28-day inhalation rat
study; metabolism study.

Needed: in first instance an in vivo
micronucleus assay with an appropriate
route (other than inhalation) and if negative
an in vivo UDS assay should be performed.
RIVM/FR/TNO SDS, February 2000 =
CS/'PM/2421 REV. II/18370.
(Adopted at the 121 SCF meeting (20 June
2000))
http://europa.eu.int/comm/food/fs/sc/scf/out
62_en.pdf
+
18400
000592-42-7 1,5-Hexadiene
D
7
Available: 4-week rat study by inhalation
and mutagenicity tests.
Needed: migration data and gene mutation
in mammalian cells in vitro. If migration
exceeds 0.05 mg/kg of food, additional
study according to SCF guidelines should
be supplied.
+
18430
000116-15-4 Hexafluoropropylene
DIR SML = ND (DL = 0.01
mg/kg)
4A
Not detectable.
Available: gene mutation assay in bacteria
(negative); chromosomal aberration assay in
cultured mammalian cells (positive); gene
mutation assay in cultured mammalian cells
(negative); micronucleus assay (positive);
UDS assay (negative).
RIVM SDS, October 2000 = CS/PM/923
REV. I/18430.
+
+