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DWAE = Dose without adverse effect (mg/kg body weight
)
A/TDI = Acceptable/tolerable daily intake
(mg/kg body weight
)
= DWAE/SF
Animal
Human
SML = specific migration limit (mg/dm
2
packaging)
= TDI x 10 (mg / dm
2
)
SML = specific migration limit (mg/kg food)
= TDI x 60 (mg/kg food)
Safety factor
= SF = 10 x 10
1 consumer of 60 kg
eats each day 1 kg food
1 kg of food in contact with 6 dm
2
Risk of over-protection ?
Food
Packaging
HOW TO REGULATE ?
EU APPROACH